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I have about 12 fields that are filterable and select some combinations for 6 or more fields cpu loads happen very high and page is waiting, waiting, waiting... No problem 6 or less filters at the same time. I use simple select and multiselect fields for filterable fields.
See this topic: http://www.mightyextensions.com/support-desk-forum/item/tickets-topics/32-resources/24974-how-much-maximum-filter-number-limit-at-the-same-time
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